By Selma OransayEndometriosis: Investigating Theoretical Causes and Pathogenesis
By Selma Oransay
Understanding the etiology of endometriosis is crucial for preventing its occurrence and minimizing the significant health burdens it imposes on women. As current treatment options are limited and often lead to severe side effects, identifying potential causes can empower women…
Key Points Lay Summary
Unviling the role of PD-1-PD-L1 Pathway in Endometriosis Progression and Therapy
The role of immune system in Endometriosis, a chronic inflammatory disease is complex, involving both protective and harmful effects. A key player in this process is PD-1 (programmed cell death protein 1), a protein found on T cells that regulates immune responses by inhibiting…
Key Points Lay Summary
By Nasuhi Engin AydinNew horizons in endometriosis and immunity
By Nasuhi Engin Aydin
Academicians led by Dorota Suszczyk from Lublin, Poland have published their recent comprehensive narrative review on immunity and endometriosis in International Journal of Molecular Sciences. Recent evidence points to the importance of co-inhibitory immune checkpoints which could be related to endometriosis mechanisms…
Key Points Lay Summary
By Eylül GÜNRegulatory T cells influence on endometriosis development
By Eylül GÜN
While the exact cause of endometriosis is still debated, various theories are being investigated. One approach focuses on the immune system. Regulatory T-cells (Tregs) are crucial in suppressing inflammatory immune responses and preventing autoimmune diseases, allergies, infections, and cancer. Knez…
Key Points Lay Summary
Stem cells may open new horizons in various gynecological disorders
By Nasuhi Engin Aydin
In-Sun Hong, PhD, a researcher in regenerative medicine at Korean Gachon University has published a comprehensive review on the role of stem cells in gynecological disorders in a recent issue of the International Journal of Biological Sciences. Endometrium changes the menstrual…
Key Points Lay Summary
By Özge ÖzkayaStudy Sheds Light on the Molecular Mechanism of Endometriosis Lesion Formation
By Özge Özkaya
The production of a protein called Nucleotide-binding Oligomerization Domain 1 (NOD1) in ectopic mesenchymal stem cells may be associated with the formation of ectopic endometrial lesions, according to a new study published in the International Journal of Stem Cells. This…
Key Points Lay Summary
Sacral neuromodulation for endometriosis-related chronic pelvic pain
By Selma Oransay
Sacral neuromodulation is a therapeutic technique that involves electrical stimulation of a sacral nerve route to modulate a neural pathway. The device is an implantable neurostimulator, and the procedure is a minimally invasive procedure with good long-term outcomes. This technique…
Key Points Lay Summary
Endometriosis of the skeletal muscular system
By Eylül GÜN
Endometriosis of the skeletal muscular system (ESMS) is characterized by the presence of endometrial cells in skeletal muscles, bones, or joints. Despite its rare occurrence, ESMS has been reported in various muscle and joint locations, leading to atypical symptoms and…
Key Points Lay Summary
By Bahar YukselPreoperative MRI: A Valuable Tool for Diagnosing Deep Infiltrating Endometriosis
By Bahar Yuksel
The article by Sebastian Harth et al. is a retrospective study that aimed to evaluate the diagnostic accuracy of preoperative magnetic resonance imaging in detecting deep infiltrating endometriosis based on specific morphological criteria. The study included 160 patients who underwent…
Key Points Lay Summary
Conditioned medium from adipose tissue derived stem cells for endometriosis treatment
By Eylül GÜN
Despite the effectiveness of both surgical and medical treatments in addressing complications related to endometriosis, there is still a high recurrence rate indicating the need for the development of novel therapeutic approaches to enhance the effectiveness of endometriosis treatment. Adipose-derived…
Key Points Lay Summary
Preoperative MRI Scoring System Could Ensure Women Are Fully Informed
By Özge Özkaya
The Deep Pelvic Endometriosis Index is able to predict the length of surgery and hospital stay as well as complications following surgery including voiding dysfunction, according to a new multicenter cohort study, the results of which were published in The Journal…
Key Points Lay Summary
The effect of glucocorticoid use on clinical pregnancy rates
By Selma Oransay
The preference to use glucocorticoids such as dexamethasone, prednisone, and methylprednisolone, along with IVF-ET cycles is due to the diminishing inflammatory response and suppressing immunity. Thus, while autoimmune diseases are suppressed with glucocorticoid administration, the success rate in the implantation…
Key Points Lay Summary
The cost-effectiveness of different GnRH agonist regimes for progestogen-resistant endometriosis.
By Selma Oransay
Surgical and medical treatments are currently used to treat the pelvic pain caused by endometriosis. Respected guidelines recommend using progestins with or without estrogens as first-line medical treatment due to their safety, effectiveness, inexpensive, and tolerability. However, one-third to one-quarter…
Key Points Lay Summary
Endometriosis disease modelling via induced pluripotent stem cells has been successful
By Nasuhi Engin Aydin
J. Julie Kim, S. Y. Hung Research Professor and Professor of ObGyn, Reproductive Science in Medicine, Northwestern University, Chicago, Illinois, has delivered a conference at the Annual International Medical Conference of the Endometriosis Foundation of America held in New York on April 1-2,…
Key Points Lay Summary
Stem cells could be a good choice for therapeutic steps in many gynecologic disorders, including endometriosis
By Nasuhi Engin Aydin
Dr. Liu from the First Hospital of Jilin University, China, and colleagues from China and the USA have published their comprehensive review on the therapeutic gateways of stem cells in female genital tract disorders in a recent issue of Life…
Key Points Lay Summary
Endometriosis and the possible mechanisms of pain.
By Selma Oransay
The most common clinical symptoms of endometriosis are chronic pelvic pain and infertility. It is often not enough to treat pain symptoms with hormonal therapy or a surgical approach. Moreover, the stage of endometriosis has weakly associated with the amount,…
Key Points Lay Summary
T-cell-targeted immunotherapy and immune checkpoint inhibitors for the treatment of endometriosis
By Nasuhi Engin Aydin
Dr. Monika Abraimuk and colleagues from Poland published their review on "the importance of immunity in endometriosis" in a recent issue of the medical journal “Cellular Signaling”. A great challenge in contemporary medical issues is endometriosis which still lacks a…
Key Points Lay Summary
A call for mast cells from endometriotic lesions
By Bahar Yuksel
Endometriosis is a well-known hormonal-dependent inflammatory disease. But what type of inflammatory cells is responsible, and when does estrogen take part, are questions that have not been answered yet. In the study conducted by Alison McCallion et al, the role…
Key Points Lay Summary
An important matter to revise: Immune system changes in endometriosis
By Eylül GÜN
Endometriosis is a multifactorial disease with unclear and obscure pathogenetic mechanisms. In their review, Chopyak et al. revised the immunopathogenic pathways that are proven and/or thought to be responsible for disease development and progression. The article was published in the…
Key Points Lay Summary
The effects of resveratrol on endometriotic cells
By Eylül GÜN
The current treatment methods for endometriosis still carry recurrence risks and side effects from medications. Herbal medicine has been investigated and used as an additional alternative method. Derived from several plants and found in some dietary sources, resveratrol is a…
Key Points Lay Summary
Genomic evidence: The recognition of endometriosis as an inflammatory systemic disease
By Nasuhi Engin Aydin
Dr. Bao and associates from Shangai-China published a new article on the genomic features of endometriosis that could yield information on its inflammatory basis and possible therapeutic potential in a recent issue of “Frontiers ın Immunology”. Endometriosis is a systemic process…
Key Points Lay Summary
The consequence of COVID-19 pandemic on endometriosis patients
By Selma Oransay
The relevant policies and restrictions concerning Covid-19 have prevented patients from accessing medical care. Similarly, standard care for endometriosis patients has also been negatively impacted by postponed or canceled appointments and suspended surgeries across the countries. Women trying to cope…
Key Points Lay Summary
A comparison of endometriosis Classifications: rASRM, EFI or Enzian?
By Selma Oransay
None of the endometriosis classifications provide a clinically valuable system since the very first description of the disease in 1860. One unique terminology to describe the localization and the extension of the disease is needed, which should be the same…
Key Points Lay Summary
Pain During Sex in Women With Endometriosis
By Özge Özkaya
Pain during intercourse or dyspareunia due to endometriosis manifests itself in multiple forms such as deep, introital, and/or positional. Pain can also occur at orgasm and during and/or after intercourse. These are the findings of a systemic literature review published…
Key Points Lay Summary
Etiopathogenesis of Endometriosis and Links with Endometrial Cancer
By Nasuhi Engin Aydin
Professor Terzic and colleagues from the Medical School of Nazarbayev University, Kazakhstan published their review on the molecular aspects of endometriosis and endometrial cancer in “International Journal of Molecular Sciences”. The etiopathogenesis of endometriosis has remained controversial, with recent studies…
Key Points Lay Summary
Exploring a bonafide biomarker to predict endometriosis
By Eylül GÜN
Endometriosis is a complex disease affecting many women in the reproductive age group. As it is important to figure out the mechanisms responsible for the disease, it is also crucial to identify biomarkers that can be used in the diagnosis…
Key Points Lay Summary
By Hale Goksever CelikDoes exercise have an effect on pain perception in women with endometriosis?
By Hale Goksever Celik
Endometriosis is an inflammatory disease causing pain symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain, and also infertility. Several medical and surgical treatment options have been developed to improve quality of life of these women. Despite extensive research, the optimal…
Key Points Lay Summary
Endometrial epithelial stem/progenitor cells have links to endometriosis with potential therapeutic research aspects
By Nasuhi Engin Aydin
Dr. Cousins with colleagues from Australia and the USA published their review paper on a not well-known subject, the epithelial stem/progenitor cells of the endometrium. This interesting paper is recently published in the scientific journal named "Frontiers in Cell and Developmental…
Key Points Lay Summary
Endometriosis and the risk of Systemic lupus Erythematosus: A report from Taiwan
By Selma Oransay
Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage that affects mostly women, with an M:F ratio of 1:9. Recent evidence has also shown that endometriosis is…
Key Points Lay Summary
By Yu Yu"Complement" of immune system and endometriosis therapeutics
By Yu Yu
The complement system is part of the body’s immune system, and plays integral roles in the recognition and clearance of pathogens, apoptotic and necrotic cells. It is composed of over 50 proteins with soluble activation precursor components, regulators and cell…
Key Points Lay Summary
The origin of macrophages determines the fate of endometriosis
By Yu Yu
Macrophages are diverse cells. They can present in all tissues of the body to perform crucial functions in immunity, homeostasis, repair and many more. Macrophages change their role depending on signals from their environment, and can therefore have a variety…
Key Points Lay Summary
The role of hormonal treatment after endometriosis surgery
By Bahar Yuksel
Postoperative hormonal suppression after endometriosis surgery still does not have a uniform approach. The meta-analysis study conducted by Zakhari et al. aimed to find a significant answer regarding this burden. They analyzed the database systems including MEDLINE, Embase, Cochrane CENTRAL,…
Key Points Lay Summary
Endometriosis and Inflammation: How to Treat it?
By Özge Özkaya
Women with endometriosis have systemic and localized inflammation within eutopic and ectopic endometrial tissues found in a study published in the "American Journal of Reproductive Immunology". More importantly, the study also found that the inflammation caused by the disease could…
Key Points Lay Summary
Segmental bowel resection could be predicted using MRI in patients with rectal endometriosis
By Hale Goksever Celik
The rectum and recto-sigmoid junction are the preferential localisations of bowel endometriosis. The three main surgical approaches are shaving, disc excision, and segmental resection. It is very important to decide the most appropriate surgical method preoperatively and to plan accordingly. …
Key Points Lay Summary
By Dr. Youngran ParkStem cell and exosome therapy
By Dr. Youngran Park
These days, two experimental methods, stem cell, and exosome therapy are getting more attention. Stem cell therapy has shown promising effects in regenerative medicine, including myocardial infarction, nervous system impairment, retinal damage, and liver diseases. Recent studies showed that stem…
Key Points Lay Summary
Woof Woof – Bone marrow cells are coming
By Yu Yu
Bone marrow contains cells that can travel to multiple organ sites and differentiate into specific tissue cells. Bone marrow-derived stem cells have also been associated with the pathogenesis of endometriosis. These cells can affect epithelial and stromal cell regeneration both…
Key Points Lay Summary
Endometriotic mesenchymal stem cells may promote endometriosis
By Yu Yu
The cause of endometriosis is still debatable. Many researchers have accepted that retrograde menstruation, where the endometrial fragments released during menstruation attach and colonize the ectopic locations, is the most plausible reason. However, the numbers just do not add up.…
Key Points Lay Summary
Fallopian tubes and endometriosis
By Selma Oransay
There are multiple theories to explain the pathogenesis of endometriosis, among which the most popular one is Sampson's retrograde menstruation theory. The role of endometrial stem cells/progenitors are widely studied to support the origin of ectopic lesions in recent decades.…
Key Points Lay Summary
Racial and ethnic disparities and women health
By Selma Oransay
The well documented racial and ethnic disparities in Obstetrics and Gynecology in the US make available to use them as an indicator of implicit bias in giving unequal health and care service to minorities. Dr. Bryant from Massachusetts General Hospital,…
Key Points Lay Summary
White blood cell neutrophils link to immunosuppressive environment in ovarian endometrioma
By Yu Yu
Recently the contribution of neutrophils to the pathogenesis of endometriosis has been suggested. Several observations fuelled this suggestion, such as the accumulation of neutrophils in the peritoneal fluid of ovarian endometriosis; neutrophil extracellular traps were found in the peritoneal fluid of…
Key Points Lay Summary
New Insights on Infertility and Low Success Rates of Assisted Reproduction in Women with Endometriosis
By Özge Özkaya
The fluid surrounding immature eggs waiting to mature and be fertilized by a sperm to lead to pregnancy is different in women with endometriosis compared to those without, according to a study published in Molecular Biology Reports. This could explain,…
Key Points Lay Summary
Early Life Factors for Endometriosis
By Dr. Youngran Park
Endometriosis affects approximately 10% of reproductive-aged women. Despite the significant impact, the etiology of endometriosis is still unclear. A recent systematic review of 15 studies of adolescents found that overall 65% of girls undergoing laparoscopic investigation were diagnosed with endometriosis.…
Key Points Lay Summary
By Irem OnurThe prevalence and severity of endometriosis today
By Irem Onur
Ghiasi M. et al., a group of researchers from the USA, presented a comprehensive review of the prevalence, incidence, and stage of endometriosis worldwide as reported over the past 30 years. Researchers performed a search in four databases, including PubMed,…
Key Points Lay Summary
The association between endometriosis and ectopic pregnancy
By Hale Goksever Celik
Endometriosis is a chronic inflammatory disease with a broad spectrum of symptoms such as dysmenorrhea, dyspareunia, chronic pelvic pain and fertility problems. It has been understood in the light of scientific evidence that endometriosis is also associated with other poor…
Key Points Lay Summary
CXCR4 or CXCR7 antagonists as novel therapies for endometriosis
By Dr. Youngran Park
Endometriosis is a common, estrogen-dependent chronic inflammatory disorder. It affects approximately 5-10% of reproductive-aged women and 20-50% of infertile women. Endometriosis also has a significant social and psychological impact on the lives of women. Despite such a significant burden, there…
Key Points Lay Summary
A comprehensive review on the etiopathogenesis of endometriosis
By Nasuhi Engin Aydin
Endometriosis, being a heterogeneous disease has a highly complex etiopathogenesis. A multicenter comprehensive review on this important subject from Italy, Germany, and the USA by Lagana and associates, was recently published in the "International Journal of Molecular Sciences" an open-access journal. Computerized…
Key Points Lay Summary
Surgery and the endometriosis associated-pain: A systematic review
By Selma Oransay
The surgical approach for pelvic pain-related to endometriosis depends on the stage and the type of the endometriotic lesion and ranging from ablation and the excision of the lesions to radical surgery as hysterectomy with removal of ovaries and presacral…
Key Points Lay Summary
Immune environment of endometriosis
By Yu Yu
The results from the past decade of research have shown that an altered pro-inflammatory immune environment in endometriosis is believed to contribute to the pathophysiology of the disease. Because of changes in the immune microenvironment in the disease state, the…
Key Points Lay Summary
A rigorous literature review on endometriosis
By Irem Onur
Bulun SE. et al., from Feinberg School of Medicine, Northwestern University, Chicago, conducted a rigorous literature review on endometriosis. This outstanding review by Dr. Bulun et al. addresses the definition, remarkable medical features, clinically useful research findings, prevalence and distribution,…
Key Points Lay Summary
Heme impairs macrophage phagocytosis
By Yu Yu
Heme is an iron-containing molecule that carries oxygen in the blood and also serves many essential biological proteins. It is released from ruptured erythrocytes during hemolysis. If not chelated, heme can cause harmful oxidative damage and inflammation. Thus, heme is…
Key Points Lay Summary
Control on endometriosis progression by a "tyrosine kinase inhibitor"
By Irem Onur
B cells, which are important players of the immune system, are increased in the blood and peritoneal cavity of endometriosis patients. Activation of B cells and the presence of anti-endometrial autoantibodies have been also been described in women with endometriosis,…
Key Points Lay Summary
The reason for lower BMI and less body fat in women with endometriosis.
By Selma Oransay
Zolbin et al. from the Department of Obstetrics and Gynecology of Yale School of Medicine, New Haven, USA, recently published the results of their prospective controlled research on adipocyte alterations in endometriosis, in the journal "Reproductive Biology and Endocrinology". Endometriosis can…
Key Points Lay Summary
Endometriosis and nuclear receptors
By Dr. Youngran Park
It is well recognized that endometriosis is a steroid-dependent disorder. In endometrial stromal cells, progesterone regulates retinoic acid production and action. Retinoids also act via a number of nuclear receptors (NRs) and are involved in normal endometrial function and endometriosis. Estrogen…
Key Points Lay Summary
Correlation between Treg cells and peritoneal lesions in women with ovarian endometrioma
By Yu Yu
It is increasingly suggested that defective immune response is responsible for the survival and development of ectopic endometrial cells into endometriosis. In women with endometriosis, the immune system fails to create an inflammatory process that destroys endometrial cells at the…
Key Points Lay Summary
A newly found relationship between estrogen signalling and immune dysregulation in endometriosis
By Yu Yu
It is believed that endometriosis progression is "at least partly" due to dysregulation of immune cells resulting in the poor clearance of ectopic endometrial debris. In particular, aberrant macrophage function was found to be important in the establishment of endometriosis, since…
Key Points Lay Summary
Anti-inflammatory cytokines: a new horizon in endometriosis with possible clinical relevance
By Nasuhi Engin Aydin
Scientists led by Dr. Li from Shangai PRC, have made a comprehensive review of anti-inflammatory cytokines related to the pathogenesis of endometriosis in a recent issue of Cellular and Molecular Life Sciences. Inflammation is important in the pathogenesis of endometriosis,…
Key Points Lay Summary
Menstrual blood-derived stem cells
By Selma Oransay
Chen et al. from the Center of Diagnosis and Treatment of İnfectious Disease, Zhejiang University, China penned this recent review in the Journal of Stem Cell Research Therapy which is presenting the clinical potential of MenSCs (Menstrual blood-derived stem cells). …
Key Points Lay Summary
Local inflammation and disease severity in endometriosis
By Yu Yu
During inflammation, immune cell receptors recognize endogenous molecules called danger-associated molecular patterns (DAMPs) or ‘alarmins’. This process reflects tissue damage and is mediated upon cell death in the condition of strong inflammation. HMGB1 and IL-33 are important DAMP molecules. Recently,…
Key Points Lay Summary
New scientific evidence supporting robotic surgical approach to ureteric endometriosis
By Nasuhi Engin Aydin
Surgical treatment of ureteral endometriosis aims to relieve urinary obstruction besides preserving renal functions. In accomplishing these, the best method of surgical approach is still unclear. Andrea Giannini and her colleagues from the University of Pisa, Italy conducted a retrospective…
Key Points Lay Summary
Is the mystery for progression of endometriosis hiding out in abnormally located endometrial cells?
By Selma Oransay
This prospective study was conducted by Hapangama et al. in Research İnstute of the University of Liverpool, UK, and the results have recently published in the Journal of Human Reproduction. The authors hypothesized that abnormally located endometrial basalis-like (SSEA1/nSOX9+)cells could be contributing to…
Key Points Lay Summary
Endometriosis-associated pain control by contraceptive implant or intrauterine system
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial glandular and stromal cells outside the uterine cavity. The most common symptoms are dysmenorrhea, dyspareunia, and chronic pelvic pain, all of which affect the quality of women’s lives. Several studies investigating the…
Key Points Lay Summary
Immune dysregulation in endometriosis
By Yu Yu
The connection between endometriosis and the immune system has long been proposed. However, to date, there is no real consensus on whether immune adaptations actually facilitate endometriotric lesion progression or they are a consequence of endometriosis re-occurrence. Thus, this article…
Key Points Lay Summary
Another Study Suggesting That Endometriosis May Be a Disease Associated With Immune System Dysfunction
By Özge Özkaya
An immune system protein called TGF-β in the peritoneal fluid or fluid that lubricates the lining of the abdominal wall and pelvic cavity may be creating an environment favorable for the formation of endometrial lesions. This is according to a…
Key Points Lay Summary
Cosmetics and some household products could be responsible for worsening endometriosis.
By Selma Oransay
A controlled clinical study recently published in the Journal of Human Reproductive Sciences, composed by Nazir et al. from the University of Health Sciences, Lahore, Pakistan. The study compared the blood diethyl hexyl phthalate (DEHP) levels of fifty infertile women laparoscopically diagnosed…
Key Points Lay Summary
Angiotensin receptor MAS1 may have a role in the pathogenesis of endometriosis
By Nasuhi Engin Aydin
Takahiro Nakajima and colleagues from Nihon University School of Medicine, Tokyo, Japan report their novel findings on Angiotensin receptor MAS1 in the pathogenesis of endometriosis in Gynecologic and Obstetrics Investigation. The renin-angiotensin system (RAS) is an activation cascade playing a…
Key Points Lay Summary
By Deniz KocasQuestionnaire based evaluation of sexual life after laparoscopic surgery for endometriosis
By Deniz Kocas
Researchers from Denmark note that laparoscopic surgery is being increasingly used for the treatment of endometriosis due to its safety and effectiveness. However, treatment success is often evaluated through follow-up on the experience of pain, leaving other important aspects of…
Key Points Lay Summary
Can we predict the complexity of laparoscopic surgery by ultrasound?
By Selma Oransay
This is a multicentric, retrospective cohort study recently published in the Journal of Minimally Invasive Gynecology by Tompsett et al. in which the results of the transvaginal ultrasonographic examinations (TVS) are compared to the results of the laparoscopic operations performed…
Key Points Lay Summary
Endometriosis Development: Pathogenesis and genomics
By Selma Oransay
In this review recently published in the International Journal of Molecular Sciences, Baranow et al from Saint Petersburg, Russia, hypothesize the existence of an endometriosis development genetic program (EMDP) that governs the origin of endometrium stem cells programmed for endometriosis; their transition…
Key Points Lay Summary
Altered Immunity in Endometriosis
By Yu Yu
In recent years, there has been increased attention on the role of immune system in endometriosis development. Normally, immune reactions are supposed to destroy endometrial cells seeding in the peritoneal cavity. Nonetheless, in endometriosis, these cells are able to evade,…
Key Points Lay Summary
By Murat OsmanTherapeutic strategies involving uterine stem cells in reproductive medicine
By Murat Osman
Stem cells are undifferentiated cells that often serve to regenerate tissue in states of injury or apoptosis. The endometrium has progenitor cells that replace tissue lost after each menstrual cycle. It has been postulated that excessive stem cell recruitment to…
Key Points Lay Summary
By Kasthuri NairAbnormal Regulation of Pathways Seen in Endometriosis
By Kasthuri Nair
Sikora et al., a team from the Medical University of Silesia in Katowice, published a study in the Archives of Gynecology and Obstetrics titled “The role of complement components C1q, MBL and C1 inhibitor in the pathogenesis of endometriosis.” It has been said that complement system…
Key Points Lay Summary
Stem cell therapy for the premature ovarian failure
By Dr. Youngran Park
Premature ovarian failure (POF) is one of the common disorders found in women. The cause of POF is not fully known, but various factors have been suggested. In genetically, X and autosomes chromosome abnormalities could result in some POF. The…
Key Points Lay Summary
Picture This: 8K UHD Television System for Endometriosis Surgery
By Kasthuri Nair
This case report by Aoki et al. was published in the journal "Videosurgery and Other Miniinvasive Techniques" under the title “Effect of an 8K ultra-high-definition television system in a case of laparoscopic gynecologic surgery.” In this publication, the authors delineated…
Key Points Lay Summary
Mechanism for Migration of Endometriosis Cells in the Body
By Kasthuri Nair
Li et al. recently published a paper in Stem Cells titled “Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis.” This article seeks to understand the mechanisms underlying the migration of endometriosis. The authors initially hypothesize that endometriosis-derived mesenchymal stem cells…
Key Points Lay Summary
Endocrine and inflammatory factors in current understanding of endometriosis
By Yu Yu
There are three forms of endometriosis: peritoneal, ovarian, and deep infiltrating. All three forms consist of endometriotic lesions containing endometrial glands, stroma, nerves, blood vessels, and inflammatory cells. Endometriosis symptoms can be accounted by these elements and the involving organs.…
Key Points Lay Summary
Endometrial stem cells and Endometriosis
By Dr. Youngran Park
Human endometrium is a cyclically proliferative tissue, and this monthly regeneration is likely mediated by endometrial stem (or progenitor) cells.The upper functional layer of the endometrium breaks down and is shed into the uterine cavity during menstruation. Re-epithelialization and repair…
Key Points Lay Summary
The endometrial stem cell markers notch-1 and numb are associated with endometriosis.
By Dr. Youngran Park
The pathological mechanisms of endometriosis are still poorly understood. However, stem cells have been candidates of interest because of their high proliferation potential and their ability to differentiate into multiple lineages, contributing to characteristic traits of endometriosis. Also, previous studies…
Key Points Lay Summary
How good are the current guidelines on endometriosis?
By Dr. Youngran Park
The endometriosis was first described in 1860, yet the etiology and pathogenesis remain poorly understood. Treatment strategies vary significantly between disease severity and the symptoms of pain and/or subfertility. These challenges have resulted in multidirectional research, and the comparability of…
Key Points Lay Summary
By Demet Candaş GreenGestational diabetes risk in women with endometriosis
By Demet Candaş Green
Gestational diabetes (GD) is a common complication in pregnancy with several negative consequences for both mother and baby. The risk of developing GD increases with maternal age and body mass index (BMI). Women with endometriosis conceive later than fertile women,…
Key Points Lay Summary
EFA Medical Conference 2017: "Cells Are the New Cure" Presentation by Dr. Max Gomez
By Kasthuri Nair
Dr. Max Gomez is an award-winning broadcast journalist, CBS News Medical Correspondent, and a presenter at the EFA 2017 Medical Conference. Dr. Gomez’s presentation was titled “Cells Are the New Cure: The Cutting-Edge Medical Breakthroughs That Are Transforming Our Health.”…
Key Points Lay Summary
The role of the B lymphocytes in endometriosis: A systematic review
By Murat Osman
Insight into the role of an inflammatory response in endometriosis has sparked further study into the role of different immune cells and their causal relationship to the pathogenesis of endometriosis. Several recent studies have found an association between aberrant immune…
Key Points Lay Summary
New Scoring System to Identify Bowel Endometriosis Syndrome
By Özge Özkaya
Researchers in Denmark have developed a new scoring system to identify women with bowel endometriosis syndrome (BENS) and monitor the effect of treatments on the syndrome. The scoring system that can be used in everyday clinical practice is the first…
Key Points Lay Summary
Characteristics and location of extrapelvic endometriosis
By Demet Candaş Green
The authors of this study reviewed the medical records of 1000 women with endometriosis from two geographical areas, New Haven, US and Crete, Greece over a 20-year period with a goal of identifying the presence and location of extrapelvic endometriosis…
Key Points Lay Summary
Human Endometrium-Derived Mesenchymal Stem Cells for Cell-based Therapies
By Yu Yu
Mesenchymal stem cells are a promising candidate for cell-based targeted therapies because they have characteristics such as self-renewal, multipotency, low immunogenicity, and non-oncogenicity. It has the capacity to migrate to sites of inflammation including in endometrial lesions and tumor. Most…
Key Points Lay Summary
Endometriosis : A Whole Body Disease
By Kasthuri Nair
Endometriosis is a disease that impacts multiple parts of an individual’s body. Seminars in Reproductive Medicine recently published a paper by Alderman III et al. entitled “The Systemic Effects of Endometriosis” explores the various comorbidities that can affect individuals suffering…
Key Points Lay Summary
TFF3 May Be Involved in Endometriosis Research Suggests
By Özge Özkaya
Levels of a protein called TFF3 are significantly increased in the peritoneal cavity (the abdominal space) of women with endometriosis, found a study published in the scientific journal Reproductive Sciences. This increase was in line with levels of other known…
Lay Summary